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Cognitive aspects of educational attainment

HLA-B · rs2523573

Where this position leads

Condition: Educational Attainment

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs2523573 Condition: Educational Attainment Educational Attainment Condition Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs2523573 rs2523573 HLA-B

What the study found

Who was studied 257,700 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0753 lower (95% confidence interval 0.053-0.098); p = 3 × 10−11.

How common The C allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of HLA-B.

What each result means

C/C Two copies of the version the research linked to Cognitive aspects of educational attainment. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Cognitive aspects of educational attainment. That is a smaller link than two copies.
G/G No copy of the version the research linked to Cognitive aspects of educational attainment. This is the starting point the study compared everyone against.
Source
Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction
Demange PA, Malanchini M, Mallard TT, Biroli P, Cox SR, Grotzinger AD, Tucker-Drob EM, Abdellaoui A, Arseneault L, van Bergen E, Boomsma DI, Caspi A
and 15 more — show all
Corcoran DL, Domingue BW, Harris KM, Ip HF, Mitchell C, Moffitt TE, Poulton R, Prinz JA, Sugden K, Wertz J, Williams BS, de Zeeuw EL, Belsky DW, Harden KP, Nivard MG
Nature genetics · 2021 · PMID 33414549 · open access

Questions about rs2523573

What is rs2523573?

rs2523573 is a single position in the genome, in or near the HLA-B gene. Published research associates it with cognitive aspects of educational attainment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2523573 linked to?

On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.

Does rs2523573 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs2523573 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2523573 come from?

GWAS Catalog, Nature genetics 2021, PMID:33414549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cognitive aspects of educational attainment (rs2523573). MyGeneLog™. https://www.mygenelog.com/variants/rs2523573

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