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MHC class I polypeptide-related sequence A levels

HLA-B · rs2523570

Where this position leads

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

What the study found

Who was studied 997 European ancestry individuals; replicated in 338 Greater Middle Eastern (Middle Eastern, North African or Persian), South Asian ancestry, Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.57 higher (95% confidence interval 0.46-0.68); p = 3 × 10⁻²².

Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of HLA-B.

What each result means

C/C No copy of the version the research linked to MHC class I polypeptide-related sequence A levels. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to MHC class I polypeptide-related sequence A levels. That is a smaller link than two copies.

T/T Two copies of the version the research linked to MHC class I polypeptide-related sequence A levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Connecting genetic risk to disease end points through the human blood plasma proteome

Suhre K, Arnold M, Bhagwat AM, Cotton RJ, Engelke R, Raffler J, Sarwath H, Thareja G, Wahl A, DeLisle RK, Gold L, Pezer M

and 12 more — show all

Lauc G, El-Din Selim MA, Mook-Kanamori DO, Al-Dous EK, Mohamoud YA, Malek J, Strauch K, Grallert H, Peters A, Kastenmüller G, Gieger C, Graumann J

Nature communications · 2017 · PMID 28240269 · open access

Questions about rs2523570

What is rs2523570?

rs2523570 is a single position in the genome, in or near the HLA-B gene. Published research associates it with mhc class i polypeptide-related sequence a levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs2523570 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs2523570 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2523570 come from?

GWAS Catalog, Nature communications 2017, PMID:28240269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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MHC class I polypeptide-related sequence A levels (rs2523570). MyGeneLog™. https://www.mygenelog.com/variants/rs2523570

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