Standard

Waist-hip index

HLA-B · rs2442725

Where this position leads

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs2442725 Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs2442725 rs2442725 HLA-B

What the study found

Who was studied 219,872 British ancestry women.

The effect Each copy of the T allele shifted the measure 0.0168 lower (95% confidence interval 0.011-0.023); p = 4 × 10−8.

Where it sits Chromosome 6, band 6p21.33 — between genes, 1.7 kb from HLA-B.

What each result means

C/C No copy of the version the research linked to Waist-hip index. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Waist-hip index. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Waist-hip index. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2442725

What is rs2442725?

rs2442725 is a single position in the genome, in or near the HLA-B gene. Published research associates it with waist-hip index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs2442725 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs2442725 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2442725 come from?

GWAS Catalog, Scientific reports 2021, PMID:34021172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Waist-hip index (rs2442725). MyGeneLog™. https://www.mygenelog.com/variants/rs2442725

← See all variants