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A body shape index

HLA-B · rs2257269

Where this position leads

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine, Lamotrigine (Lamictal)

rs2257269 Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug Drug: Lamotrigine (Lamictal) Lamotrigine (Lamictal) Drug rs2257269 rs2257269 HLA-B

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 219,872 British ancestry women.

The effect Each copy of the A allele shifted the measure 0.0159 higher (95% confidence interval 0.01-0.022); p = 3 × 10−8.

Where it sits Chromosome 6, band 6p21.33 — a synonymous change in HLA-B.

What each result means

A/A Two copies of the version the research linked to A body shape index. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to A body shape index. That is a smaller link than two copies.
G/G No copy of the version the research linked to A body shape index. This is the starting point the study compared everyone against.
Source
GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer
Christakoudi S, Evangelou E, Riboli E, Tsilidis KK
Scientific reports · 2021 · PMID 34021172 · open access

Questions about rs2257269

What is rs2257269?

rs2257269 is a single position in the genome, in or near the HLA-B gene. Published research associates it with a body shape index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs2257269 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine, Lamotrigine (Lamictal). That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs2257269 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2257269 come from?

GWAS Catalog, Scientific reports 2021, PMID:34021172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

A body shape index (rs2257269). MyGeneLog™. https://www.mygenelog.com/variants/rs2257269

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