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Who was studied 98,316 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.000937 lower (95% confidence interval 0.00073-0.00115); p = 8 × 10−19.
How common The A allele had a frequency of about 33% in the people studied.
Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.
What each result means
A/ATwo copies of the version the research linked to Citrate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Citrate levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Citrate levels. This is the starting point the study compared everyone against.
Ophthalmology science · 2024 · PMID 39091897 · open access
Questions about rs2199766
What is rs2199766?
rs2199766 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with citrate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2199766 linked to?
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
Does rs2199766 affect how medicines work?
SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs2199766 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2199766 come from?
GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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