Free Cholesterol to Cholesteryl Esters in Small HDL ratio
CFTR · rs145380885
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Who was studied 98,316 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.212 higher (95% confidence interval 0.15-0.27); p = 2 × 10−11.
How common The C allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 7, band 7q31.2 — in an intron of CFTR.
What each result means
C/CTwo copies of the version the research linked to Free Cholesterol to Cholesteryl Esters in Small HDL ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Free Cholesterol to Cholesteryl Esters in Small HDL ratio. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Free Cholesterol to Cholesteryl Esters in Small HDL ratio. This is the starting point the study compared everyone against.
Ophthalmology science · 2024 · PMID 39091897 · open access
Questions about rs145380885
What is rs145380885?
rs145380885 is a single position in the genome, in or near the CFTR gene. Published research associates it with free cholesterol to cholesteryl esters in small hdl ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs145380885 linked to?
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
Does rs145380885 affect how medicines work?
CFTR carries pharmacogenomic findings for Elexacaftor/tezacaftor/ivacaftor (Trikafta), Ivacaftor, Vanzacaftor/tezacaftor/deutivacaftor (Alyftrek). That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs145380885 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs145380885 come from?
GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 251223116Reads by AI crawlersClaude0ChatGPT0Google · Gemini1Perplexity2Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others16Total25Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Free Cholesterol to Cholesteryl Esters in Small HDL ratio (rs145380885). MyGeneLog™. https://www.mygenelog.com/variants/rs145380885