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MHC class I polypeptide-related sequence A levels

HLA-B · rs13213324

Where this position leads

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs13213324 Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs13213324 rs13213324 HLA-B

What the study found

Who was studied 2,935 Qatari ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.369 higher (95% confidence interval 0.31-0.43); p = 1 × 10−33.

How common The G allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in an intron of HLA-B.

What each result means

C/C No copy of the version the research linked to MHC class I polypeptide-related sequence A levels. This is the starting point the study compared everyone against.
C/G One copy of the version the research linked to MHC class I polypeptide-related sequence A levels. That is a smaller link than two copies.
G/G Two copies of the version the research linked to MHC class I polypeptide-related sequence A levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs13213324

What is rs13213324?

rs13213324 is a single position in the genome, in or near the HLA-B gene. Published research associates it with mhc class i polypeptide-related sequence a levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs13213324 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs13213324 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13213324 come from?

GWAS Catalog, Human molecular genetics 2023, PMID:36168886. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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MHC class I polypeptide-related sequence A levels (rs13213324). MyGeneLog™. https://www.mygenelog.com/variants/rs13213324

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