C/TOne copy of NUDT15*3, a no-function allele. NUDT15 removes the active thiopurine metabolites once they have done their work; without it they accumulate in dividing cells. CPIC notes these alleles are common in Asian and Hispanic populations and predispose to myelosuppression, and recommends a reduced starting dose.
T/TTwo copies of NUDT15*3. Severe thiopurine toxicity at standard doses is expected rather than possible, and CPIC recommends drastically reduced dosing or an alternative. A TPMT test alone would have missed this, which is why the guideline now covers both genes.
This is a pharmacogenomic result with a published dosing guideline behind it. Tell a prescriber or pharmacist rather than acting on it — and never stop or change a prescribed medicine on the strength of a genotype.
Source: CPIC Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update, Clinical Pharmacology & Therapeutics (PMID 30447069).
Questions about rs116855232
What is rs116855232?
rs116855232 is a single position in the genome, in or near the NUDT15 gene. Published research associates it with nudt15 *3 — thiopurine tolerance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs116855232 affect how medicines work?
NUDT15 carries pharmacogenomic findings for Thiopurines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs116855232 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs116855232 come from?
CPIC Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update, Clinical Pharmacology & Therapeutics (PMID 30447069). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.