Gene Knowledge Graph UTC
Sensitive

Schizophrenia

HLA-B · rs116509918

Where this position leads

Condition: Schizophrenia

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs116509918 Condition: Schizophrenia Schizophrenia Condition Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs116509918 rs116509918 HLA-B

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Schizophrenia compared to the general population. (GWAS Catalog, Schizophr Bull 2018, PMID:30285260)
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Schizophrenia. (GWAS Catalog, Schizophr Bull 2018, PMID:30285260)
T/T Published research associates this genotype with typical/baseline likelihood of Schizophrenia — no copies of the reported risk allele. (GWAS Catalog, Schizophr Bull 2018, PMID:30285260)
Source
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect
Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, Shimasaki A, Kawase K, Sakusabe T, Iwayama Y, Toyota T, Wakuda T
and 20 more — show all
Kikuchi M, Kanahara N, Yamamori H, Yasuda Y, Watanabe Y, Hoya S, Aleksic B, Kushima I, Arai H, Takaki M, Hattori K, Kunugi H, Okahisa Y, Ohnuma T, Ozaki N, Someya T, Hashimoto R, Yoshikawa T, Kubo M, Iwata N
Schizophrenia bulletin · 2019 · PMID 30285260

Questions about rs116509918

What is rs116509918?

rs116509918 is a single position in the genome, in or near the HLA-B gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs116509918 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does rs116509918 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs116509918 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs116509918 come from?

GWAS Catalog, Schizophr Bull 2018, PMID:30285260. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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