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Who was studied 26,279 European ancestry cases, 442,230 European ancestry controls, 2,590 South Asian ancestry cases, 1,720 South Asian ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.589 higher (95% confidence interval 0.55-0.62); p = 4 × 10−266.
Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of HLA-B.
What each result means
C/CNo copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of translational medicine · 2025 · PMID 39885523 · open access
Questions about rs115860766
What is rs115860766?
rs115860766 is a single position in the genome, in or near the HLA-B gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs115860766 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does rs115860766 affect how medicines work?
HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs115860766 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs115860766 come from?
GWAS Catalog, Journal of translational medicine 2025, PMID:39885523. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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