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Who was studied 37,846 British ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.994 lower (95% confidence interval 0.68-1.31); p = 8 × 10−10.
How common The G allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in the 3′ untranslated region of HLA-B.
What each result means
A/ANo copy of the version the research linked to Asthma (age of onset). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Asthma (age of onset). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Asthma (age of onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
The Lancet. Respiratory medicine · 2019 · PMID 31036433
Questions about rs1093
What is rs1093?
rs1093 is a single position in the genome, in or near the HLA-B gene. Published research associates it with asthma (age of onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs1093 affect how medicines work?
HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs1093 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1093 come from?
GWAS Catalog, The Lancet. Respiratory medicine 2019, PMID:31036433. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Asthma (age of onset) (rs1093). MyGeneLog™. https://www.mygenelog.com/variants/rs1093