Gene Knowledge Graph
UTC
Standard

Strep throat

HLA-B · rs1055821

Where this position leads

Condition: Tonsillectomy (Throat Infection Susceptibility)

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs1055821 Condition: Tonsillectomy (Throat Infection Susceptibility) Tonsillectomy (Throat Infection Sus… Condition Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs1055821 rs1055821 HLA-B

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of Strep throat — no copies of the reported risk allele.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Strep throat.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Strep throat compared to the general population.
Source
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections
Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA
Nature communications · 2017 · PMID 28928442 · open access

Questions about rs1055821

What is rs1055821?

rs1055821 is a single position in the genome, in or near the HLA-B gene. Published research associates it with strep throat. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1055821 linked to?

On MyGeneLog this position is linked to Tonsillectomy (Throat Infection Susceptibility). The research behind each link, and its sources, are set out on that condition page.

Does rs1055821 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs1055821 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1055821 come from?

GWAS Catalog, Nat Commun 2017, PMID:28928442. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants