2 4832236123125Reads by AI crawlersClaude3ChatGPT2Google · Gemini2Perplexity3Meta AI6Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others25Total48Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 12.945 European ancestry cases, 274,252 European ancestry controls; replicated in 4,242 European ancestry cases, 12,802 European ancestry controls.
The effect
Each copy of the C allele carried 1.11 times the odds of Basal cell carcinoma; p = 3 × 10−9.
How common The C allele had a frequency of about 75% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — a missense change in HLA-B.
What each result means
C/CTwo copies of the version the research linked to Basal cell carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Basal cell carcinoma. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Basal cell carcinoma. This is the starting point the study compared everyone against.
Nature communications · 2016 · PMID 27539887 · open access
Questions about rs1050529
What is rs1050529?
rs1050529 is a single position in the genome, in or near the HLA-B gene. Published research associates it with basal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1050529 linked to?
On MyGeneLog this position is linked to Basal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
Does rs1050529 affect how medicines work?
HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs1050529 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1050529 come from?
GWAS Catalog, Nat Commun 2016, PMID:27539887. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 4832236123125Reads by AI crawlersClaude3ChatGPT2Google · Gemini2Perplexity3Meta AI6Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others25Total48Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.