Squamous Cell Lung Carcinoma, as genome-wide studies have reported it: 2 positions from 2 studies, the largest recording 8,901 cases and 64,477 controls (European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Squamous Cell Lung Carcinoma — filed in the GWAS Catalog as "Squamous cell lung carcinoma" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 2 positions from 2 studies, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Gorman BR et al. 2024, in Nature Communications — Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk. The catalogue records its sample as 8,901 cases and 64,477 controls (European ancestry). From it, one position on this page: rs9267123 (near HCP5). PMID:39366959.
Qin N et al. 2021, in Frontiers of Medicine — Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma. Sample in the catalogue's record: 8,350 cases and 27,355 controls (European ancestry). From it, one position on this page: rs465498 (CLPTM1L). PMID:32889700.
The 2 positions lie in or near 2 genes: HCP5, CLPTM1L. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Gorman BR et al. 2024 reported the smallest P value on this page — P = 5 × 10-29, with an odds ratio of 1.30 — at rs9267123 near HCP5.
Read this page as a list of findings about Squamous Cell Lung Carcinoma, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
A genotype does not diagnose Squamous Cell Lung Carcinoma; a clinician does. No guideline uses the 2 variants on this page to predict it, screen for it or confirm it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Squamous Cell Lung Carcinoma comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Squamous Cell Lung Carcinoma. MyGeneLog™. https://www.mygenelog.com/conditions/squamous-cell-lung-carcinoma
In the GWAS Catalog, Squamous Cell Lung Carcinoma is filed as "Squamous cell lung carcinoma". Rather than define it, this page lists the genome-wide findings: 2 positions from 2 studies, each with its study's sample and citation.
Genome-wide studies have reported 2 associated positions; the largest study behind this page recorded 8,901 cases and 64,477 controls (European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 2 genes: HCP5, CLPTM1L. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Squamous Cell Lung Carcinoma is diagnosed by a clinician, and no guideline uses a genotype to predict it.
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