Gene Knowledge Graph
UTC
Sensitive

Squamous cell lung carcinoma

CLPTM1L · rs465498

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 8,350 Chinese or European ancestry cases, 27,355 Chinese or European ancestry controls.

The effect Each copy of the A allele carried 1.21 times the odds of Squamous cell lung carcinoma (95% confidence interval 1.16-1.26); p = 6 × 10−18.

Where it sits Chromosome 5, band 5p15.33 — in an intron of CLPTM1L.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Squamous cell lung carcinoma compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Squamous cell lung carcinoma.
G/G Published research associates this genotype with typical/baseline likelihood of Squamous cell lung carcinoma — no copies of the reported risk allele.
Source
Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma
Qin N, Li Y, Wang C, Zhu M, Dai J, Hong T, Albanes D, Lam S, Tardon A, Chen C, Goodman G, Bojesen SE
and 32 more — show all
Landi MT, Johansson M, Risch A, Wichmann HE, Bickeboller H, Rennert G, Arnold S, Brennan P, Field JK, Shete S, Le Marchand L, Melander O, Brunnstrom H, Liu G, Hung RJ, Andrew A, Kiemeney LA, Zienolddiny S, Grankvist K, Johansson M, Caporaso N, Woll P, Lazarus P, Schabath MB, Aldrich MC, Stevens VL, Jin G, Christiani DC, Hu Z, Amos CI, Ma H, Shen H
Frontiers of medicine · 2021 · PMID 32889700

Questions about rs465498

What is rs465498?

rs465498 is a single position in the genome, in or near the CLPTM1L gene. Published research associates it with squamous cell lung carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs465498 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs465498 come from?

GWAS Catalog, Frontiers of medicine 2021, PMID:32889700. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Squamous cell lung carcinoma (rs465498). MyGeneLog™. https://www.mygenelog.com/variants/rs465498

← See all variants