Sensitive

Squamous cell lung carcinoma

near HCP5 · rs9267123

Where this position leads

Condition: Squamous Cell Lung Carcinoma

rs9267123 Condition: Squamous Cell Lung Carcinoma Squamous Cell Lung Carcinoma Condition rs9267123 rs9267123 near HCP5

What the study found

Who was studied 8,901 European ancestry cases, 64,477 European ancestry controls; replicated in 4,162 European ancestry cases, 13,599 European ancestry controls.

The effect Each copy of the C allele carried 1.30 times the odds of Squamous cell lung carcinoma (95% confidence interval 1.246-1.368); p = 5 × 10−29.

How common The C allele had a frequency of about 12% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 3.5 kb from HCP5.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Squamous cell lung carcinoma compared to the general population.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Squamous cell lung carcinoma.
G/G Published research associates this genotype with typical/baseline likelihood of Squamous cell lung carcinoma — no copies of the reported risk allele.
Source

Questions about rs9267123

What is rs9267123?

rs9267123 is a single position in the genome, in or near the near HCP5 gene. Published research associates it with squamous cell lung carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9267123 linked to?

On MyGeneLog this position is linked to Squamous Cell Lung Carcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs9267123 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9267123 come from?

GWAS Catalog, Nature communications 2024, PMID:39366959. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Squamous cell lung carcinoma (rs9267123). MyGeneLog™. https://www.mygenelog.com/variants/rs9267123

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