Spinal Stenosis, as genome-wide studies have reported it: 2 positions from 1 study, the largest recording 61,730 cases and 545,165 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Genome-wide studies have so far placed 2 positions on Spinal Stenosis, from 1 study; the GWAS Catalog files the condition as "Spinal stenosis (PheCode 720)". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Sample in the catalogue's record: 61,730 cases and 545,165 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). It contributes 2 positions: rs11635145 (SMAD3), rs34616559 (SOX5). PMID:39024449.
The 2 positions sit in or beside 2 genes: SMAD3, SOX5. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Of all these, rs11635145 in SMAD3 carries the strongest signal: P = 10-22, in Verma A et al. 2024.
Read this page as a list of findings about Spinal Stenosis, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
A genotype does not diagnose Spinal Stenosis; a clinician does. No guideline uses the 2 variants on this page to predict it, screen for it or confirm it.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Spinal Stenosis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Spinal Stenosis. MyGeneLog™. https://www.mygenelog.com/conditions/spinal-stenosis
In the GWAS Catalog, Spinal Stenosis is filed as "Spinal stenosis (PheCode 720)". Rather than define it, this page lists the genome-wide findings: 2 positions from 1 study, each with its study's sample and citation.
Genes play a part: 2 positions have been linked to it, the largest study recording 61,730 cases and 545,165 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The catalogue maps the positions to 2 genes: SMAD3, SOX5. These are where the positions sit, not proof of how they act.
No. They are population-level findings of small effect. Spinal Stenosis is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.