Sialoadenitis, as genome-wide studies have reported it: 7 positions from 1 study, the largest recording 2,458 cases and 626,856 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Genome-wide studies have so far placed 7 positions on Sialoadenitis, from 1 study; the GWAS Catalog files the condition as "Sialoadenitis (PheCode 527.2)". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 2,458 cases and 626,856 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). It contributes 7 positions: rs577531651 (ZNF3), rs111504352 (near SUMO2P2), rs576990442 (BCO1), rs370265927 (VEPH1), rs529204084 (EPB41L2), rs140691871 (RCAN2-DT), rs372229555 (LHFPL2). PMID:39024449.
The 7 positions lie in or near 7 genes: ZNF3, SUMO2P2, BCO1, VEPH1, EPB41L2, RCAN2-DT, LHFPL2. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Of all these, rs577531651 in ZNF3 carries the strongest signal: P = 10-13, in Verma A et al. 2024.
It is a record of what genome-wide studies have reported about Sialoadenitis, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Nothing on this page diagnoses Sialoadenitis. The 7 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Sialoadenitis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Sialoadenitis. MyGeneLog™. https://www.mygenelog.com/conditions/sialoadenitis
In the GWAS Catalog, Sialoadenitis is filed as "Sialoadenitis (PheCode 527.2)". Rather than define it, this page lists the genome-wide findings: 7 positions from 1 study, each with its study's sample and citation.
Genome-wide studies have reported 7 associated positions; the largest study behind this page recorded 2,458 cases and 626,856 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 7 genes: ZNF3, SUMO2P2, BCO1, VEPH1, EPB41L2, RCAN2-DT, LHFPL2. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Sialoadenitis is diagnosed by a clinician, and no guideline uses a genotype to predict it.
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