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Who was studied 572 African American or Afro-Caribbean cases, 120,485 African American or Afro-Caribbean controls, 1,651 European ancestry cases, 447,070 European ancestry controls, 235 Hispanic or Latin American cases, 59,301 Hispanic or Latin American controls.
The effect
Each copy of the C allele shifted the measure 3.77 lower (95% confidence interval 3.75-3.78); p = 1 × 10−13.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 7, band 7q22.1 — in an intron of ZNF3.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Sialoadenitis (PheCode 527.2) compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Sialoadenitis (PheCode 527.2).
T/TPublished research associates this genotype with typical/baseline likelihood of Sialoadenitis (PheCode 527.2) — no copies of the reported risk allele.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs577531651
What is rs577531651?
rs577531651 is a single position in the genome, in or near the ZNF3 gene. Published research associates it with sialoadenitis (phecode 527.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs577531651 linked to?
On MyGeneLog this position is linked to Sialoadenitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs577531651 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs577531651 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 44Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0Others4Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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