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Who was studied 572 African American or Afro-Caribbean cases, 120,485 African American or Afro-Caribbean controls, 1,651 European ancestry cases, 447,070 European ancestry controls, 235 Hispanic or Latin American cases, 59,301 Hispanic or Latin American controls.
The effect
Each copy of the C allele shifted the measure 2.63 lower (95% confidence interval 2.59-2.67); p = 4 × 10−11.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 10, band 10q26.2 — in an intron of ADAM12.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Sialoadenitis (PheCode 527.2) compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Sialoadenitis (PheCode 527.2).
T/TPublished research associates this genotype with typical/baseline likelihood of Sialoadenitis (PheCode 527.2) — no copies of the reported risk allele.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs186288708
What is rs186288708?
rs186288708 is a single position in the genome, in or near the ADAM12 gene. Published research associates it with sialoadenitis (phecode 527.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs186288708 linked to?
On MyGeneLog this position is linked to Sialoadenitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs186288708 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs186288708 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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