Pyogenic Granuloma, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 1,065 cases and 569,509 controls (African American or Afro-Caribbean ancestry, European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Genome-wide studies have so far placed 5 positions on Pyogenic Granuloma, from 1 study; the GWAS Catalog files the condition as "Pyogenic granuloma (PheCode 686.4)". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. The catalogue records its sample as 1,065 cases and 569,509 controls (African American or Afro-Caribbean ancestry, European ancestry). From it, 5 positions on this page: rs189587536 (CDH4), rs368835767 (LINC01698), rs146121743 (near FAM149B1P1), rs562007239 (ZNF480), rs145666765 (LINC02262). PMID:39024449.
The 5 positions sit in or beside 5 genes: CDH4, LINC01698, FAM149B1P1, ZNF480, LINC02262. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Of all these, rs189587536 in CDH4 carries the strongest signal: P = 10-13, in Verma A et al. 2024.
It is a record of what genome-wide studies have reported about Pyogenic Granuloma, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Pyogenic Granuloma is diagnosed by a clinician — not from a genotype. None of the 5 variants on this page is used by any guideline to predict, screen for or diagnose it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Pyogenic Granuloma comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Pyogenic Granuloma. MyGeneLog™. https://www.mygenelog.com/conditions/pyogenic-granuloma
In the GWAS Catalog, Pyogenic Granuloma is filed as "Pyogenic granuloma (PheCode 686.4)". Rather than define it, this page lists the genome-wide findings: 5 positions from 1 study, each with its study's sample and citation.
Genome-wide studies have reported 5 associated positions; the largest study behind this page recorded 1,065 cases and 569,509 controls (African American or Afro-Caribbean ancestry, European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 5 genes: CDH4, LINC01698, FAM149B1P1, ZNF480, LINC02262. These are where the positions sit, not proof of how they act.
No. They are population-level findings of small effect. Pyogenic Granuloma is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.