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Who was studied 275 African American or Afro-Caribbean cases, 121,138 African American or Afro-Caribbean controls, 790 European ancestry cases, 448,371 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 4.17 lower (95% confidence interval 4.16-4.18); p = 1 × 10−12.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 15, band 15q26.2 — between genes, 22.9 kb from FAM149B1P1.
What each result means
A/ANo copy of the version the research linked to Pyogenic granuloma (PheCode 686.4). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Pyogenic granuloma (PheCode 686.4). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Pyogenic granuloma (PheCode 686.4). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs146121743
What is rs146121743?
rs146121743 is a single position in the genome, in or near the near FAM149B1P1 gene. Published research associates it with pyogenic granuloma (phecode 686.4). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs146121743 linked to?
On MyGeneLog this position is linked to Pyogenic Granuloma. The research behind each link, and its sources, are set out on that condition page.
Does having rs146121743 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs146121743 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 5122Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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