Peyronie's Disease, as genome-wide studies have reported it: 7 positions from 1 study, the largest recording 3,199 cases and 571,377 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Genome-wide studies have so far placed 7 positions on Peyronie's Disease, from 1 study; the GWAS Catalog files the condition as "Peyronie's disease (PheCode 604.3)". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Sample in the catalogue's record: 3,199 cases and 571,377 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). The 7 positions on this page from it: rs10226248 (near WNT2), rs528539364 (FOXP1), rs143888834 (near LINC02836), rs1040551 (near RN7SL636P), rs555372783 (SKIC8), rs1239296705 (SPTLC2), rs574927914 (ZFP90). PMID:39024449.
The 7 positions lie in or near 7 genes: WNT2, FOXP1, LINC02836, RN7SL636P, SKIC8, SPTLC2, ZFP90. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
The strongest association in the records is rs10226248 near WNT2, reported by Verma A et al. 2024 at P = 10-37.
It is a record of what genome-wide studies have reported about Peyronie's Disease, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
A genotype does not diagnose Peyronie's Disease; a clinician does. No guideline uses the 7 variants on this page to predict it, screen for it or confirm it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Peyronie's Disease comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Peyronie's Disease. MyGeneLog™. https://www.mygenelog.com/conditions/peyronies-disease
Peyronie's Disease is the condition the GWAS Catalog files under "Peyronie's disease (PheCode 604.3)". This page does not define it in its own words; it lists what genome-wide studies have reported: 7 positions from 1 study, with each study's sample and citation.
Genes play a part: 7 positions have been linked to it, the largest study recording 3,199 cases and 571,377 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 7 genes: WNT2, FOXP1, LINC02836, RN7SL636P, SKIC8, SPTLC2, ZFP90. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Peyronie's Disease from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.