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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 8,968 African American cases, 79,530 African American controls, 24,867 European ancestry cases, 296,446 European ancestry controls, 2,527 Hispanic American cases, 32,334 Hispanic American controls, 1,399 African ancestry cases, 1,450 African ancestry controls.
The effect
Each copy of the C allele shifted the measure 5.57 z score lower; p = 3 × 10−8.
How common The C allele had a frequency of about 98% in the people studied.
Where it sits Chromosome 19, band 19p13.11 — in an intron of KCNN1.
What each result means
C/CTwo copies of the version the research linked to Opioid use disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Opioid use disorder. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Opioid use disorder. This is the starting point the study compared everyone against.
rs112068658 is a single position in the genome, in or near the KCNN1 gene. Published research associates it with opioid use disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs112068658 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs112068658 come from?
GWAS Catalog, Nature neuroscience 2022, PMID:36171425. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Opioid use disorder (rs112068658). MyGeneLog™. https://www.mygenelog.com/variants/rs112068658