Non-proliferative Glomerulonephritis, as genome-wide studies have reported it: 6 positions from 1 study, the largest recording 967 cases and 571,873 controls (African American or Afro-Caribbean ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
1 study in the GWAS Catalog report 6 positions for Non-proliferative Glomerulonephritis, which the catalogue files as "Non-proliferative glomerulonephritis (PheCode 580.12)". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Sample in the catalogue's record: 967 cases and 571,873 controls (African American or Afro-Caribbean ancestry, European ancestry). It contributes 6 positions: rs181546322 (near EPHB3), rs534424363 (near HNRNPA1P69), rs546099707 (KLF13), rs115824929 (NRXN1), rs138496035 (near Y_RNA), rs570978087 (near TMEM132E). PMID:39024449.
The catalogue maps the 6 positions to 6 genes: EPHB3, HNRNPA1P69, KLF13, NRXN1, Y_RNA, TMEM132E. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Of all these, rs181546322 near EPHB3 carries the strongest signal: P = 8 × 10-13, in Verma A et al. 2024.
Association records say which positions differ, on average, between people with Non-proliferative Glomerulonephritis and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Nothing on this page diagnoses Non-proliferative Glomerulonephritis. The 6 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Non-proliferative Glomerulonephritis comes down to these specific, well-studied positions — not a diagnosis.
near HNRNPA1P69 · rs534424363
See detailed info →near EPHB3 · rs181546322
See detailed info →KLF13 · rs546099707
See detailed info →NRXN1 · rs115824929
See detailed info →near Y_RNA · rs138496035
See detailed info →near TMEM132E · rs570978087
See detailed info →Databases, guidelines and references
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Non-proliferative Glomerulonephritis. MyGeneLog™. https://www.mygenelog.com/conditions/non-proliferative-glomerulonephritis
Non-proliferative Glomerulonephritis is the condition the GWAS Catalog files under "Non-proliferative glomerulonephritis (PheCode 580.12)". This page does not define it in its own words; it lists what genome-wide studies have reported: 6 positions from 1 study, with each study's sample and citation.
Genes play a part: 6 positions have been linked to it, the largest study recording 967 cases and 571,873 controls (African American or Afro-Caribbean ancestry, European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 6 genes: EPHB3, HNRNPA1P69, KLF13, NRXN1, Y_RNA, TMEM132E. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Non-proliferative Glomerulonephritis is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.