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Who was studied 411 African American or Afro-Caribbean cases, 121,350 African American or Afro-Caribbean controls, 556 European ancestry cases, 450,523 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 4.1 lower (95% confidence interval 4.09-4.11); p = 2 × 10−12.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 12, band 12q14.2 — between genes, 1.4 kb from HNRNPA1P69.
What each result means
A/ANo copy of the version the research linked to Non-proliferative glomerulonephritis (PheCode 580.12). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Non-proliferative glomerulonephritis (PheCode 580.12). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Non-proliferative glomerulonephritis (PheCode 580.12). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs534424363
What is rs534424363?
rs534424363 is a single position in the genome, in or near the near HNRNPA1P69 gene. Published research associates it with non-proliferative glomerulonephritis (phecode 580.12). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs534424363 linked to?
On MyGeneLog this position is linked to Non-proliferative Glomerulonephritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs534424363 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs534424363 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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