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Non-proliferative glomerulonephritis (PheCode 580.12)

NRXN1 · rs115824929

Where this position leads

Condition: Non-proliferative Glomerulonephritis

rs115824929 Condition: Non-proliferative Glomerulonephritis Non-proliferative Glomerulonephritis Condition rs115824929 rs115824929 NRXN1

What the study found

Who was studied 411 African American or Afro-Caribbean cases, 121,350 African American or Afro-Caribbean controls, 556 European ancestry cases, 450,523 European ancestry controls.

The effect Each copy of the A allele shifted the measure 2.69 lower (95% confidence interval 2.65-2.73); p = 4 × 10−12.

How common The A allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 2, band 2p16.3 — in an intron of NRXN1.

What each result means

A/A Two copies of the version the research linked to Non-proliferative glomerulonephritis (PheCode 580.12). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Non-proliferative glomerulonephritis (PheCode 580.12). That is a smaller link than two copies.
G/G No copy of the version the research linked to Non-proliferative glomerulonephritis (PheCode 580.12). This is the starting point the study compared everyone against.
Source

Questions about rs115824929

What is rs115824929?

rs115824929 is a single position in the genome, in or near the NRXN1 gene. Published research associates it with non-proliferative glomerulonephritis (phecode 580.12). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs115824929 linked to?

On MyGeneLog this position is linked to Non-proliferative Glomerulonephritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs115824929 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs115824929 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Non-proliferative glomerulonephritis (PheCode 580.12) (rs115824929). MyGeneLog™. https://www.mygenelog.com/variants/rs115824929

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