Meningitis, as genome-wide studies have reported it: 8 positions from 2 studies, the largest recording 1,180 cases and 570,786 controls (African American or Afro-Caribbean ancestry, European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
2 studies in the GWAS Catalog report 8 positions for Meningitis, which the catalogue files as "Meningitis". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Sample in the catalogue's record: 1,180 cases and 570,786 controls (African American or Afro-Caribbean ancestry, European ancestry). From it, 4 positions on this page: rs182754811 (near EEPD1), rs543029525 (NRP2), rs377608659 (near ICE2P1), rs190161374 (RIN3). PMID:39024449.
Gelemanović A et al. 2023, in International Journal of Molecular Sciences — Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk. Sample in the catalogue's record: 30 cases and 4,594 controls. The 4 positions on this page from it: rs13358188 (SGCD), rs17587821 (ITPKB), rs189257688 (near CD28), rs188530871 (SCAPER). PMID:37108169.
The 8 positions sit in or beside 8 genes: EEPD1, NRP2, ICE2P1, RIN3, SGCD, ITPKB, CD28, SCAPER. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
The strongest association in the records is rs13358188 in SGCD, reported by Gelemanović A et al. 2023 at P = 8 × 10-13, with an odds ratio of 1.10.
It is a record of what genome-wide studies have reported about Meningitis, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Nothing on this page diagnoses Meningitis. The 8 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Meningitis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Meningitis. MyGeneLog™. https://www.mygenelog.com/conditions/meningitis
Meningitis is the condition the GWAS Catalog files under "Meningitis". This page does not define it in its own words; it lists what genome-wide studies have reported: 8 positions from 2 studies, with each study's sample and citation.
Genes play a part: 8 positions have been linked to it, the largest study recording 1,180 cases and 570,786 controls (African American or Afro-Caribbean ancestry, European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 8 genes: EEPD1, NRP2, ICE2P1, RIN3, SGCD, ITPKB, CD28, SCAPER. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Meningitis from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.