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Who was studied 308 African American or Afro-Caribbean cases, 121,301 African American or Afro-Caribbean controls, 872 European ancestry cases, 449,485 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 2.11 lower (95% confidence interval 2.05-2.16); p = 1 × 10−11.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 4, band 4q35.2 — between genes, 5 kb from ICE2P1.
What each result means
C/CTwo copies of the version the research linked to Meningitis (PheCode 320). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Meningitis (PheCode 320). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Meningitis (PheCode 320). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs377608659
What is rs377608659?
rs377608659 is a single position in the genome, in or near the near ICE2P1 gene. Published research associates it with meningitis (phecode 320). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs377608659 linked to?
On MyGeneLog this position is linked to Meningitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs377608659 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs377608659 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 4112Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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