KRT5 · rs638907
Where this position leads
Condition: Keratinocyte Cancer
What the study found
Who was studied at least 18,538 European ancestry cases, at least 340,302 European ancestry controls.
The effect Each copy of the G allele carried 1.11 times the odds of Keratinocyte cancer (MTAG) (95% confidence interval 1.08-1.13); p = 2 × 10−23.
How common The G allele had a frequency of about 73% in the people studied.
Where it sits Chromosome 12, band 12q13.13 — in an intron of KRT5.
What ClinVar records
Classification
Benign for Epidermolysis bullosa simplex; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 6 submitters), last evaluated 2026-02-01.
ClinVar record 66264 NM_000424.4(KRT5):c.555+9C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs638907 is a single position in the genome, in or near the KRT5 gene. Published research associates it with keratinocyte cancer (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Keratinocyte Cancer. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Human molecular genetics 2019, PMID:31174203. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Keratinocyte cancer (MTAG) (rs638907). MyGeneLog™. https://www.mygenelog.com/variants/rs638907