Intervertebral Disc Disorder, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 58,854 cases and 922,958 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Genome-wide studies have so far placed 5 positions on Intervertebral Disc Disorder, from 1 study; the GWAS Catalog files the condition as "ICD10 M51: Intervertebral disc disorder". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Bjornsdottir G et al. 2022, in Nature Communications — Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology. Studied in 58,854 cases and 922,958 controls (European ancestry). From it, 5 positions on this page: rs3135842 (FGFR3), rs4757353 (LINC02751), rs28487989 (SLC25A21), rs16934882 (C8orf34), rs3010044 (COLGALT2). PMID:35110524.
The 5 positions sit in or beside 5 genes: FGFR3, LINC02751, SLC25A21, C8orf34, COLGALT2. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Bjornsdottir G et al. 2022 reported the smallest P value on this page — P = 4 × 10-14, with an odds ratio of 0.95 — at rs3135842 in FGFR3.
Association records say which positions differ, on average, between people with Intervertebral Disc Disorder and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
A genotype does not diagnose Intervertebral Disc Disorder; a clinician does. No guideline uses the 5 variants on this page to predict it, screen for it or confirm it.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Intervertebral Disc Disorder comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Intervertebral Disc Disorder. MyGeneLog™. https://www.mygenelog.com/conditions/intervertebral-disc-disorder
Intervertebral Disc Disorder is the condition the GWAS Catalog files under "ICD10 M51: Intervertebral disc disorder". This page does not define it in its own words; it lists what genome-wide studies have reported: 5 positions from 1 study, with each study's sample and citation.
Genes play a part: 5 positions have been linked to it, the largest study recording 58,854 cases and 922,958 controls (European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 5 genes: FGFR3, LINC02751, SLC25A21, C8orf34, COLGALT2. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Intervertebral Disc Disorder from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.