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Who was studied 58,854 European ancestry cases, 922,958 European ancestry controls.
The effect
Each copy of the C allele carried 0.95 times the odds of ICD10 M51: Intervertebral disc disorder (95% confidence interval 0.93-0.96); p = 4 × 10−14.
How common The C allele had a frequency of about 27% in the people studied.
Where it sits Chromosome 4, band 4p16.3 — in an intron of FGFR3.
What each result means
C/CTwo copies of the version the research linked to ICD10 M51: Intervertebral disc disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to ICD10 M51: Intervertebral disc disorder. That is a smaller link than two copies.
G/GNo copy of the version the research linked to ICD10 M51: Intervertebral disc disorder. This is the starting point the study compared everyone against.
Nature communications · 2022 · PMID 35110524 · open access
Questions about rs3135842
What is rs3135842?
rs3135842 is a single position in the genome, in or near the FGFR3 gene. Published research associates it with icd10 m51: intervertebral disc disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3135842 linked to?
On MyGeneLog this position is linked to Intervertebral Disc Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs3135842 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3135842 come from?
GWAS Catalog, Nature communications 2022, PMID:35110524. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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