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Who was studied 58,854 European ancestry cases, 922,958 European ancestry controls.
The effect
Each copy of the C allele carried 0.95 times the odds of ICD10 M51: Intervertebral disc disorder (95% confidence interval 0.93-0.96); p = 3 × 10−12.
How common The C allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 14, band 14q13.3 — in an intron of SLC25A21.
What each result means
C/CTwo copies of the version the research linked to ICD10 M51: Intervertebral disc disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to ICD10 M51: Intervertebral disc disorder. That is a smaller link than two copies.
T/TNo copy of the version the research linked to ICD10 M51: Intervertebral disc disorder. This is the starting point the study compared everyone against.
Nature communications · 2022 · PMID 35110524 · open access
Questions about rs28487989
What is rs28487989?
rs28487989 is a single position in the genome, in or near the SLC25A21 gene. Published research associates it with icd10 m51: intervertebral disc disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs28487989 linked to?
On MyGeneLog this position is linked to Intervertebral Disc Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs28487989 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28487989 come from?
GWAS Catalog, Nature communications 2022, PMID:35110524. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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