Idiopathic Membranous Nephropathy, as genome-wide studies have reported it: 4 positions from 1 study, the largest recording 556 cases and 2,338 controls (European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Genome-wide studies have so far placed 4 positions on Idiopathic Membranous Nephropathy, from 1 study; the GWAS Catalog files the condition as "Idiopathic membranous nephropathy". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Stanescu HC et al. 2011, in The New England Journal of Medicine — Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. Sample in the catalogue's record: 556 cases and 2,338 controls (European ancestry). From it, 4 positions on this page: rs7775397 (c6orf10), rs3130564 (PSORS1C1), rs3129939 (c6orf10), rs4664308 (LY75). PMID:21323541.
The catalogue maps the 4 positions to 3 genes: c6orf10, PSORS1C1, LY75. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
The strongest association in the records is rs7775397 in c6orf10, reported by Stanescu HC et al. 2011 at P = 5 × 10-71, with an odds ratio of 3.83.
It is a record of what genome-wide studies have reported about Idiopathic Membranous Nephropathy, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Idiopathic Membranous Nephropathy is diagnosed by a clinician — not from a genotype. None of the 4 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Idiopathic Membranous Nephropathy comes down to these specific, well-studied positions — not a diagnosis.
The studies behind these variants recruited participants from different ancestries — a result found in one population doesn't always transfer to another. Based on 4 of 4 linked studies with a resolved discovery ancestry.
Databases, guidelines and references
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Idiopathic Membranous Nephropathy. MyGeneLog™. https://www.mygenelog.com/conditions/idiopathic-membranous-nephropathy
Idiopathic Membranous Nephropathy is the condition the GWAS Catalog files under "Idiopathic membranous nephropathy". This page does not define it in its own words; it lists what genome-wide studies have reported: 4 positions from 1 study, with each study's sample and citation.
Genes play a part: 4 positions have been linked to it, the largest study recording 556 cases and 2,338 controls (European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 3 genes: c6orf10, PSORS1C1, LY75. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Idiopathic Membranous Nephropathy is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.