Dermatophytosis
Dermatophytosis, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 256,822 European, African, Hispanic or Latin American and Asian ancestry cases, 1,372,501 European, African, Hispanic or Latin American and Asian ancestry controls. Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
What this condition connects to
Genome-wide studies have so far placed 5 positions on Dermatophytosis, from 1 study; the GWAS Catalog files the condition as "ICD10 B35: Dermatophytosis". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Where the positions come from
Haapaniemi H et al. 2026, in Nature Communications — The genetic basis of dermatophytosis skin infection susceptibility. Studied in 256,822 European, African, Hispanic or Latin American and Asian ancestry cases, 1,372,501 European, African, Hispanic or Latin American and Asian ancestry controls. It contributes 5 positions: rs7196726 (ZNF646), rs10094888 (near LYNX1-SLURP2), rs2236506 (RTEL1), rs612057 (near HCAR2), rs62066119 (near RPS26P8). PMID:41792138.
The positions
The catalogue maps the 5 positions to 5 genes: ZNF646, LYNX1-SLURP2, RTEL1, HCAR2, RPS26P8. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Haapaniemi H et al. 2026 reported the smallest P value on this page — P = 7 × 10-79, with an odds ratio of 1.07 — at rs7196726 in ZNF646.
What this page is, and is not
Read this page as a list of findings about Dermatophytosis, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
In the news
2026-03-06 · Haapaniemi H et al. The genetic basis of dermatophytosis skin infection susceptibility. Nature Communications 2026, PMID:41792138
Fungal skin infection runs partly in the genes — and through obesity genes
Dermatophytosis — the fungal infection behind athlete's foot, nail fungus and ringworm — affects around 20% of the world's population. A genome-wide meta-analysis of over 250,000 cases from FinnGen, the Estonian Biobank, UK Biobank and the Million Veteran Program found 30 genome-wide significant loci, with top signals near ZNF646, HLA-DQB1, FLG, FTO, SLURP2 and KRT77, and pointed to keratin biology, the skin barrier, immune function and obesity. 19 of the study's positions already have pages here, including rs1421085 in FTO, the best-known obesity position, and five on the dermatophytosis page. PMID:41792138.
From our blog
Clinical detail
Genotype and diagnosis
Nothing on this page diagnoses Dermatophytosis. The 5 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
Related variants MyGeneLog™ checks for
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Dermatophytosis comes down to these specific, well-studied positions — not a diagnosis.
Sources
Databases, guidelines and references
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Dermatophytosis. MyGeneLog™. https://www.mygenelog.com/conditions/icd10-b35-dermatophytosis
Questions about Dermatophytosis
What is Dermatophytosis?
In the GWAS Catalog, Dermatophytosis is filed as "ICD10 B35: Dermatophytosis". Rather than define it, this page lists the genome-wide findings: 5 positions from 1 study, each with its study's sample and citation.
Is Dermatophytosis genetic?
Genes play a part: 5 positions have been linked to it, the largest study recording 256,822 European, African, Hispanic or Latin American and Asian ancestry cases, 1,372,501 European, African, Hispanic or Latin American and Asian ancestry controls. But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
Which genes are linked to Dermatophytosis on this page?
The positions lie in or near 5 genes: ZNF646, LYNX1-SLURP2, RTEL1, HCAR2, RPS26P8. A mapped gene is the catalogue's location for a position, not a mechanism.
Can these variants predict whether I will get Dermatophytosis?
No. They are population-level findings of small effect. Dermatophytosis is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.