RTEL1 · rs2236506
Where this position leads
Condition: Dermatophytosis
What the study found
Who was studied 256,822 European, African, Hispanic or Latin American and Asian ancestry cases, 1,372,501 European, African, Hispanic or Latin American and Asian ancestry controls.
The effect Each copy of the A allele carried 0.97 times the odds of ICD10 B35: Dermatophytosis (95% confidence interval 0.959-0.9742); p = 9 × 10−15.
How common The A allele had a frequency of about 78% in the people studied.
Where it sits Chromosome 20, band 20q13.33 — a missense change in RTEL1.
What ClinVar records
Classification
Benign/Likely benign for Dyskeratosis congenita, Dyskeratosis congenita, autosomal recessive 5, Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 3; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 14 submitters), last evaluated 2026-02-04.
ClinVar record 403400 NM_001283009.2(RTEL1):c.2274G>A (p.Ala758=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2236506 is a single position in the genome, in or near the RTEL1 gene. Published research associates it with icd10 b35: dermatophytosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Dermatophytosis. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2026, PMID:41792138. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
ICD10 B35: Dermatophytosis (rs2236506). MyGeneLog™. https://www.mygenelog.com/variants/rs2236506