Gastric Ulcer, as genome-wide studies have reported it: 4 positions from 3 studies, the largest recording 28,682 cases and 867,208 controls (Japanese ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Gastric Ulcer — filed in the GWAS Catalog as "Gastric ulcer" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 4 positions from 3 studies, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
He Y et al. 2023, in Nature Genetics — East Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease. The catalogue records its sample as 28,682 cases and 867,208 controls (Japanese ancestry, European ancestry). From it, 2 positions on this page: rs17866912 (near PRELID3BP10), rs77132614 (MECOM). PMID:38036781.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Sample in the catalogue's record: 5,127 cases and 619,972 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). It contributes one position: rs558685191 (near PPM1AP1). PMID:39024449.
Sakaue S et al. 2021, in Nature Genetics — A cross-population atlas of genetic associations for 220 human phenotypes. Sample in the catalogue's record: 12,650 cases and 161,227 controls (East Asian ancestry). It contributes one position: rs371481926 (MYO9B). PMID:34594039.
The 4 positions sit in or beside 4 genes: PRELID3BP10, MECOM, PPM1AP1, MYO9B. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Verma A et al. 2024 reported the smallest P value on this page — P = 4 × 10-12 — at rs558685191 near PPM1AP1.
Read this page as a list of findings about Gastric Ulcer, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Nothing on this page diagnoses Gastric Ulcer. The 4 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Gastric Ulcer comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Gastric Ulcer. MyGeneLog™. https://www.mygenelog.com/conditions/gastric-ulcer
Gastric Ulcer is the condition the GWAS Catalog files under "Gastric ulcer". This page does not define it in its own words; it lists what genome-wide studies have reported: 4 positions from 3 studies, with each study's sample and citation.
Genome-wide studies have reported 4 associated positions; the largest study behind this page recorded 28,682 cases and 867,208 controls (Japanese ancestry, European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 4 genes: PRELID3BP10, MECOM, PPM1AP1, MYO9B. These are where the positions sit, not proof of how they act.
No. They are population-level findings of small effect. Gastric Ulcer is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.