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Gastric ulcer (PheCode 531.2)

near PPM1AP1 · rs558685191

Where this position leads

Condition: Gastric Ulcer

rs558685191 Condition: Gastric Ulcer Gastric Ulcer Condition rs558685191 rs558685191 near PPM1AP1

What the study found

Who was studied 1,070 African American or Afro-Caribbean cases, 119,145 African American or Afro-Caribbean controls, 3,640 European ancestry cases, 442,008 European ancestry controls, 417 Hispanic or Latin American cases, 58,819 Hispanic or Latin American controls.

The effect Each copy of the C allele shifted the measure 2.62 lower (95% confidence interval 2.58-2.66); p = 4 × 10−12.

How common The C allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 8, band 8p22 — between genes, 57.4 kb from PPM1AP1.

What each result means

C/C Two copies of the version the research linked to Gastric ulcer (PheCode 531.2). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Gastric ulcer (PheCode 531.2). That is a smaller link than two copies.
T/T No copy of the version the research linked to Gastric ulcer (PheCode 531.2). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs558685191

What is rs558685191?

rs558685191 is a single position in the genome, in or near the near PPM1AP1 gene. Published research associates it with gastric ulcer (phecode 531.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs558685191 linked to?

On MyGeneLog this position is linked to Gastric Ulcer. The research behind each link, and its sources, are set out on that condition page.

Does having rs558685191 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs558685191 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gastric ulcer (PheCode 531.2) (rs558685191). MyGeneLog™. https://www.mygenelog.com/variants/rs558685191

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