Dysplasia of Prostate, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 1,376 cases and 518,488 controls (African American or Afro-Caribbean ancestry, European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
1 study in the GWAS Catalog report 5 positions for Dysplasia of Prostate, which the catalogue files as "Dysplasia of prostate (PheCode 602.3)". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Sample in the catalogue's record: 1,376 cases and 518,488 controls (African American or Afro-Caribbean ancestry, European ancestry). It contributes 5 positions: rs369965030 (near HMGB3P19), rs1043744855 (near BMAL1), rs1483923524 (near IRAK1BP1), rs1050561329 (near CTD-2194D22.4), rs186112434 (CDH13). PMID:39024449.
The catalogue maps the 5 positions to 5 genes: HMGB3P19, BMAL1, IRAK1BP1, CTD-2194D22.4, CDH13. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Of all these, rs369965030 near HMGB3P19 carries the strongest signal: P = 10-12, in Verma A et al. 2024.
Association records say which positions differ, on average, between people with Dysplasia of Prostate and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
A genotype does not diagnose Dysplasia of Prostate; a clinician does. No guideline uses the 5 variants on this page to predict it, screen for it or confirm it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Dysplasia of Prostate comes down to these specific, well-studied positions — not a diagnosis.
near CTD-2194D22.4 · rs1050561329
See detailed info →Databases, guidelines and references
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Dysplasia of Prostate. MyGeneLog™. https://www.mygenelog.com/conditions/dysplasia-of-prostate
Dysplasia of Prostate is the condition the GWAS Catalog files under "Dysplasia of prostate (PheCode 602.3)". This page does not define it in its own words; it lists what genome-wide studies have reported: 5 positions from 1 study, with each study's sample and citation.
Genes play a part: 5 positions have been linked to it, the largest study recording 1,376 cases and 518,488 controls (African American or Afro-Caribbean ancestry, European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 5 genes: HMGB3P19, BMAL1, IRAK1BP1, CTD-2194D22.4, CDH13. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Dysplasia of Prostate is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.