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Dysplasia of prostate (PheCode 602.3)

near BMAL1 · rs1043744855

Where this position leads

Condition: Dysplasia of Prostate

rs1043744855 Condition: Dysplasia of Prostate Dysplasia of Prostate Condition rs1043744855 rs1043744855 near BMAL1

What the study found

Who was studied 322 African American or Afro-Caribbean cases, 103,885 African American or Afro-Caribbean controls, 1,054 European ancestry cases, 414,603 European ancestry controls.

The effect Each copy of the T allele shifted the measure 4.51 lower (95% confidence interval 4.5-4.51); p = 3 × 10−12.

How common The T allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 11, band 11p15.3 — between genes, 123.8 kb from BMAL1.

What each result means

C/C No copy of the version the research linked to Dysplasia of prostate (PheCode 602.3). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Dysplasia of prostate (PheCode 602.3). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Dysplasia of prostate (PheCode 602.3). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs1043744855

What is rs1043744855?

rs1043744855 is a single position in the genome, in or near the near BMAL1 gene. Published research associates it with dysplasia of prostate (phecode 602.3). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1043744855 linked to?

On MyGeneLog this position is linked to Dysplasia of Prostate. The research behind each link, and its sources, are set out on that condition page.

Does having rs1043744855 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1043744855 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Dysplasia of prostate (PheCode 602.3) (rs1043744855). MyGeneLog™. https://www.mygenelog.com/variants/rs1043744855

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