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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 322 African American or Afro-Caribbean cases, 103,885 African American or Afro-Caribbean controls, 1,054 European ancestry cases, 414,603 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 2.22 lower (95% confidence interval 2.16-2.27); p = 4 × 10−11.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 16, band 16q23.3 — in an intron of CDH13.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Dysplasia of prostate (PheCode 602.3) compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Dysplasia of prostate (PheCode 602.3).
T/TPublished research associates this genotype with typical/baseline likelihood of Dysplasia of prostate (PheCode 602.3) — no copies of the reported risk allele.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs186112434
What is rs186112434?
rs186112434 is a single position in the genome, in or near the CDH13 gene. Published research associates it with dysplasia of prostate (phecode 602.3). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs186112434 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs186112434 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Dysplasia of prostate (PheCode 602.3) (rs186112434). MyGeneLog™. https://www.mygenelog.com/variants/rs186112434