Cannabis Use Disorder, as genome-wide studies have reported it: 7 positions from 1 study, the largest recording 200,762 individuals (European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
This is the record of what genome-wide association studies have found for Cannabis Use Disorder (the GWAS Catalog's "Cannabis use disorder (MTAG)"): 7 positions reported by 1 study. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Levey DF et al. 2023, in Nature Genetics — Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications. Sample in the catalogue's record: 200,762 individuals (European ancestry). The 7 positions on this page from it: rs12497569 (USP4), rs11570190 (CTNND1), rs10835372 (near LINC02758), rs62461186 (MAGI2), rs1637570 (ENO4), rs850254 (OTX2-AS1), rs3897854 (DPYD). PMID:37985822.
The 7 positions lie in or near 7 genes: USP4, CTNND1, LINC02758, MAGI2, ENO4, OTX2-AS1, DPYD. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
The strongest association in the records is rs12497569 in USP4, reported by Levey DF et al. 2023 at P = 4 × 10-14.
It is a record of what genome-wide studies have reported about Cannabis Use Disorder, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
A genotype does not diagnose Cannabis Use Disorder; a clinician does. No guideline uses the 7 variants on this page to predict it, screen for it or confirm it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Cannabis Use Disorder comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Cannabis Use Disorder. MyGeneLog™. https://www.mygenelog.com/conditions/cannabis-use-disorder
In the GWAS Catalog, Cannabis Use Disorder is filed as "Cannabis use disorder (MTAG)". Rather than define it, this page lists the genome-wide findings: 7 positions from 1 study, each with its study's sample and citation.
Genome-wide studies have reported 7 associated positions; the largest study behind this page recorded 200,762 individuals (European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 7 genes: USP4, CTNND1, LINC02758, MAGI2, ENO4, OTX2-AS1, DPYD. These are where the positions sit, not proof of how they act.
No. They are population-level findings of small effect. Cannabis Use Disorder is diagnosed by a clinician, and no guideline uses a genotype to predict it.
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