Sensitive

Cannabis use disorder (MTAG)

USP4 · rs12497569

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 200,762 European ancestry individuals (MTAG effective sample size boosted by alcohol use disorder and nicotine dependence samples).

The effect Each copy of the A allele shifted the measure 0.024 lower (95% confidence interval 0.018-0.03); p = 4 × 10⁻¹⁴.

How common The A allele had a frequency of about 56% in the people studied.

Where it sits Chromosome 3, band 3p21.31 — in an intron of USP4.

What each result means

A/A Two copies of the version the research linked to Cannabis use disorder (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Cannabis use disorder (MTAG). That is a smaller link than two copies.

G/G No copy of the version the research linked to Cannabis use disorder (MTAG). This is the starting point the study compared everyone against.

Source

Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications

Levey DF, Galimberti M, Deak JD, Wendt FR, Bhattacharya A, Koller D, Harrington KM, Quaden R, Johnson EC, Gupta P, Biradar M, Lam M

and 18 more — show all

Cooke M, Rajagopal VM, Empke SLL, Zhou H, Nunez YZ, Kranzler HR, Edenberg HJ, Agrawal A, Smoller JW, Lencz T, Hougaard DM, Børglum AD, Demontis D, Gaziano JM, Gandal MJ, Polimanti R, Stein MB, Gelernter J

Veterans Affairs Million Veteran Program

Nature genetics · 2023 · PMID 37985822 · open access

Questions about rs12497569

What is rs12497569?

rs12497569 is a single position in the genome, in or near the USP4 gene. Published research associates it with cannabis use disorder (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12497569 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12497569 come from?

GWAS Catalog, Nature genetics 2023, PMID:37985822. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cannabis use disorder (MTAG) (rs12497569). MyGeneLog™. https://www.mygenelog.com/variants/rs12497569

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