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Who was studied 200,762 European ancestry individuals (MTAG effective sample size boosted by alcohol use disorder and nicotine dependence samples).
The effect
Each copy of the A allele shifted the measure 0.018 lower (95% confidence interval 0.012-0.024); p = 3 × 10−8.
How common The A allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 14, band 14q22.3 — in an intron of OTX2-AS1.
What each result means
A/ATwo copies of the version the research linked to Cannabis use disorder (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Cannabis use disorder (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Cannabis use disorder (MTAG). This is the starting point the study compared everyone against.
Nature genetics · 2023 · PMID 37985822 · open access
Questions about rs850254
What is rs850254?
rs850254 is a single position in the genome, in or near the OTX2-AS1 gene. Published research associates it with cannabis use disorder (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs850254 linked to?
On MyGeneLog this position is linked to Cannabis Use Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs850254 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs850254 come from?
GWAS Catalog, Nature genetics 2023, PMID:37985822. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cannabis use disorder (MTAG) (rs850254). MyGeneLog™. https://www.mygenelog.com/variants/rs850254