Arrhythmia, as genome-wide studies have reported it: 6 positions from 1 study, the largest recording 17,861 cases and 194,592 controls (Japanese ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
This is the record of what genome-wide association studies have found for Arrhythmia (the GWAS Catalog's "Arrhythmia"): 6 positions reported by 1 study. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Ishigaki K et al. 2020, in Nature Genetics — Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Studied in 17,861 cases and 194,592 controls (Japanese ancestry). From it, 6 positions on this page: rs373205748 (NEURL1), rs12506083 (near LINC01438), rs12253987 (NEURL1), rs73205368 (PTCHD1), rs729949 (CAV1), rs9921081 (ZFHX3-AS1). PMID:32514122.
The catalogue maps the 6 positions to 5 genes: NEURL1, LINC01438, PTCHD1, CAV1, ZFHX3-AS1. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Ishigaki K et al. 2020 reported the smallest P value on this page — P = 10-79, with an odds ratio of 4.48 — at rs373205748 in NEURL1.
Read this page as a list of findings about Arrhythmia, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Nothing on this page diagnoses Arrhythmia. The 6 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Arrhythmia comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Arrhythmia. MyGeneLog™. https://www.mygenelog.com/conditions/arrhythmia
In the GWAS Catalog, Arrhythmia is filed as "Arrhythmia". Rather than define it, this page lists the genome-wide findings: 6 positions from 1 study, each with its study's sample and citation.
Genome-wide studies have reported 6 associated positions; the largest study behind this page recorded 17,861 cases and 194,592 controls (Japanese ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 5 genes: NEURL1, LINC01438, PTCHD1, CAV1, ZFHX3-AS1. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Arrhythmia from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.