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Arrhythmia

ZFHX3-AS1 · rs9921081

Where this position leads

Condition: Arrhythmia

rs9921081 Condition: Arrhythmia Arrhythmia Condition rs9921081 rs9921081 ZFHX3-AS1

What the study found

Who was studied 17,861 Japanese ancestry cases, 194,592 Japanese ancestry controls.

The effect Each copy of the C allele carried 0.90 times the odds of Arrhythmia (95% confidence interval 0.879380616579749-0.930070403810424); p = 2 × 10−12.

Where it sits Chromosome 16, band 16q22.3 — in an intron of ZFHX3-AS1.

What each result means

C/C Two copies of the version the research linked to Arrhythmia. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Arrhythmia. That is a smaller link than two copies.
T/T No copy of the version the research linked to Arrhythmia. This is the starting point the study compared everyone against.
Source
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T
and 77 more — show all
Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y
Nature genetics · 2020 · PMID 32514122

Questions about rs9921081

What is rs9921081?

rs9921081 is a single position in the genome, in or near the ZFHX3-AS1 gene. Published research associates it with arrhythmia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9921081 linked to?

On MyGeneLog this position is linked to Arrhythmia. The research behind each link, and its sources, are set out on that condition page.

Does having rs9921081 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9921081 come from?

GWAS Catalog, Nature genetics 2020, PMID:32514122. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Arrhythmia (rs9921081). MyGeneLog™. https://www.mygenelog.com/variants/rs9921081

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