Acute Pericarditis, as genome-wide studies have reported it: 7 positions from 1 study, the largest recording 1,045 cases and 571,040 controls (African American or Afro-Caribbean ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Genome-wide studies have so far placed 7 positions on Acute Pericarditis, from 1 study; the GWAS Catalog files the condition as "Acute pericarditis (PheCode 420.21)". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 1,045 cases and 571,040 controls (African American or Afro-Caribbean ancestry, European ancestry). From it, 7 positions on this page: rs552767609 (GALNT16-AS1), rs556330122 (near HS3ST1), rs567746402 (near MIR4472-1), rs148428765 (near MRPS21P6), rs568031359 (near LINC02923), rs181673904 (DPP4), rs190370190 (near RNA5SP261). PMID:39024449.
The 7 positions lie in or near 7 genes: GALNT16-AS1, HS3ST1, MIR4472-1, MRPS21P6, LINC02923, DPP4, RNA5SP261. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Of all these, rs552767609 in GALNT16-AS1 carries the strongest signal: P = 6 × 10-13, in Verma A et al. 2024.
Read this page as a list of findings about Acute Pericarditis, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
A genotype does not diagnose Acute Pericarditis; a clinician does. No guideline uses the 7 variants on this page to predict it, screen for it or confirm it.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Acute Pericarditis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Acute Pericarditis. MyGeneLog™. https://www.mygenelog.com/conditions/acute-pericarditis
Acute Pericarditis is the condition the GWAS Catalog files under "Acute pericarditis (PheCode 420.21)". This page does not define it in its own words; it lists what genome-wide studies have reported: 7 positions from 1 study, with each study's sample and citation.
Genes play a part: 7 positions have been linked to it, the largest study recording 1,045 cases and 571,040 controls (African American or Afro-Caribbean ancestry, European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 7 genes: GALNT16-AS1, HS3ST1, MIR4472-1, MRPS21P6, LINC02923, DPP4, RNA5SP261. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Acute Pericarditis is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.