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Cancer

Acute Myeloid Leukemia

Assembled from catalogue records November 6, 2026

Acute Myeloid Leukemia, as genome-wide studies have reported it: 23 positions from 3 studies, the largest recording 358 cases and 12,938 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.

What this condition connects to

Prevalence
The records give study sizes, not how common Acute Myeloid Leukemia is, so this page gives no figure for it. For scale, the largest study here recorded 358 cases and 12,938 controls (European ancestry) (Ranasinghe D et al. 2026, PMID:41610418).
Inheritance
The records show a polygenic pattern — 23 positions from 3 studies, each a common variant of small effect. How much of Acute Myeloid Leukemia is inherited is not something they measure.

3 studies in the GWAS Catalog report 23 positions for Acute Myeloid Leukemia, which the catalogue files as "Acute myeloid leukemia". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.

The studies behind the positions

A study. The 20 positions on this page from it: rs1057519750 (RUNX1), rs1057520339 (NSD1), rs1194223999 (TERT), rs1210600080 (CEBPA), rs121913491 (FLT3), rs121913499 (IDH1), rs1313738991 (DNMT3A), rs1388478228 (CEBPA), and 12 more.

Ranasinghe D et al. 2026, in Blood — Common variation at 1q23.3, 2p23.3, 2q33.3, and 2p21 influences the risk of acute myeloid leukemia. Sample in the catalogue's record: 358 cases and 12,938 controls (European ancestry). It contributes 2 positions: rs79918355 (EPCAM-DT), rs12988876 (PARD3B). PMID:41610418.

Lin WY et al. 2021, in Nature Communications — Genome-wide association study identifies susceptibility loci for acute myeloid leukemia. Studied in 3,041 cases and 6,760 controls (European ancestry). The one position on this page from it: rs3916765 (near MTCO3P1). PMID:34716350.

Positions and mapped genes

The 23 positions lie in or near 16 genes: RUNX1, NSD1, TERT, CEBPA, FLT3, IDH1, DNMT3A, BCOR, FOXP1, SF3B1, DDX41, KRAS, MYC, EPCAM-DT, PARD3B, MTCO3P1. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.

Lin WY et al. 2021 reported the smallest P value on this page — P = 2 × 10-10, with an odds ratio of 1.72 — at rs3916765 near MTCO3P1.

What these records can and cannot tell you

Read this page as a list of findings about Acute Myeloid Leukemia, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.

Clinical detail

What is actually diagnosed and treated here

Nothing on this page diagnoses Acute Myeloid Leukemia. The 23 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.

Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.

Sources

Databases, guidelines and references

Papers, with their authors
Common variation at 1q23.3, 2p23.3, 2q33.3, and 2p21 influences the risk of acute myeloid leukemia
Ranasinghe D, Lin WY, Fordham SE, Alharbi A, Sunter NJ, Elstob C, Nahari MH, Xu Y, Park C, Hungate E, Quante A, Strauch K
and 82 more — show all
Gieger C, Skol A, Rahman T, Sucheston-Campbell L, Hahn T, Clay-Gilmour AI, Jones GL, Marr HJ, Jackson GH, Menne T, Collin M, Ivey A, Hills RK, Burnett AK, Russell NH, Fitzgibbon J, Larson RA, Le Beau MM, Stock W, Heidenreich O, Enshaei A, Gunasinghe D, Hawking ZL, Heslop H, Nandana D, Di B, Plokhuta A, Brown IT, Allsup DJ, Houlston RS, Collins A, Milne P, Norden J, Dickinson AM, Lendrem C, Daly AK, Palm L, Piechocki K, Jeffries S, Bornhäuser M, Röllig C, Altmann H, Ruhnke L, Kunadt D, Wagenführ L, Cordell HJ, Darlay R, Andersen MK, Fontana MC, Martinelli G, Marconi G, Sanz MA, Cervera J, Gómez-Seguí I, Cluzeau T, Moreilhon C, Raynaud S, Sill H, Voso MT, Dombret H, Cheok M, Preudhomme C, Gale RE, Linch D, Weisinger J, Masszi A, Nowak D, Hofmann WK, Gilkes A, Porkka K, Milosevic Feenstra JD, Kralovics R, Wang J, Meggendorfer M, Haferlach T, Krizsán S, Bödör C, Parkin B, Malek SN, Stölzel F, Onel K, Allan JM
Blood · 2026 · PMID 41610418
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
Lin WY, Fordham SE, Hungate E, Sunter NJ, Elstob C, Xu Y, Park C, Quante A, Strauch K, Gieger C, Skol A, Rahman T
and 71 more — show all
Sucheston-Campbell L, Wang J, Hahn T, Clay-Gilmour AI, Jones GL, Marr HJ, Jackson GH, Menne T, Collin M, Ivey A, Hills RK, Burnett AK, Russell NH, Fitzgibbon J, Larson RA, Le Beau MM, Stock W, Heidenreich O, Alharbi A, Allsup DJ, Houlston RS, Norden J, Dickinson AM, Douglas E, Lendrem C, Daly AK, Palm L, Piechocki K, Jeffries S, Bornhäuser M, Röllig C, Altmann H, Ruhnke L, Kunadt D, Wagenführ L, Cordell HJ, Darlay R, Andersen MK, Fontana MC, Martinelli G, Marconi G, Sanz MA, Cervera J, Gómez-Seguí I, Cluzeau T, Moreilhon C, Raynaud S, Sill H, Voso MT, Lo-Coco F, Dombret H, Cheok M, Preudhomme C, Gale RE, Linch D, Gaal-Wesinger J, Masszi A, Nowak D, Hofmann WK, Gilkes A, Porkka K, Milosevic Feenstra JD, Kralovics R, Grimwade D, Meggendorfer M, Haferlach T, Krizsán S, Bödör C, Stölzel F, Onel K, Allan JM
Nature communications · 2021 · PMID 34716350 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Acute Myeloid Leukemia. MyGeneLog™. https://www.mygenelog.com/conditions/acute-myeloid-leukemia

Questions about Acute Myeloid Leukemia

What is Acute Myeloid Leukemia?

Acute Myeloid Leukemia is the condition the GWAS Catalog files under "Acute myeloid leukemia". This page does not define it in its own words; it lists what genome-wide studies have reported: 23 positions from 3 studies, with each study's sample and citation.

Is Acute Myeloid Leukemia genetic?

Genome-wide studies have reported 23 associated positions; the largest study behind this page recorded 358 cases and 12,938 controls (European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.

Which genes are linked to Acute Myeloid Leukemia on this page?

The catalogue maps the positions to 16 genes: RUNX1, NSD1, TERT, CEBPA, FLT3, IDH1, DNMT3A, BCOR, FOXP1, SF3B1, DDX41, KRAS, MYC, EPCAM-DT, PARD3B, MTCO3P1. These are where the positions sit, not proof of how they act.

Can these variants predict whether I will get Acute Myeloid Leukemia?

No. They are population-level findings of small effect. Acute Myeloid Leukemia is diagnosed by a clinician, and no guideline uses a genotype to predict it.

Free to reuse, non-commercially. This page's text is original writing from freely-available research, licensed CC BY-NC 4.0 — share and adapt it with attribution to MyGeneLog™; commercial use is licensed. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.