Standard
Acute myeloid leukemia (normal cytogenetics)
near MTCO3P1 · rs3916765
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 3,041 European ancestry cases, 6,760 European ancestry controls; replicated in 977 European ancestry cases, 3,728 European ancestry controls.
The effect
Each copy of the G allele carried 1.72 times the odds of Acute myeloid leukemia (normal cytogenetics) (95% confidence interval 1.46-2.03); p = 2 × 10−10.
Where it sits Chromosome 6, band 6p21.32 — between genes, 10.8 kb from MTCO3P1.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of Acute myeloid leukemia (normal cytogenetics) — no copies of the reported risk allele.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Acute myeloid leukemia (normal cytogenetics).
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Acute myeloid leukemia (normal cytogenetics) compared to the general population.
Source
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
Lin WY,
Fordham SE,
Hungate E,
Sunter NJ,
Elstob C,
Xu Y,
Park C,
Quante A,
Strauch K,
Gieger C,
Skol A,
Rahman T
and 71 more — show all
Sucheston-Campbell L,
Wang J,
Hahn T,
Clay-Gilmour AI,
Jones GL,
Marr HJ,
Jackson GH,
Menne T,
Collin M,
Ivey A,
Hills RK,
Burnett AK,
Russell NH,
Fitzgibbon J,
Larson RA,
Le Beau MM,
Stock W,
Heidenreich O,
Alharbi A,
Allsup DJ,
Houlston RS,
Norden J,
Dickinson AM,
Douglas E,
Lendrem C,
Daly AK,
Palm L,
Piechocki K,
Jeffries S,
Bornhäuser M,
Röllig C,
Altmann H,
Ruhnke L,
Kunadt D,
Wagenführ L,
Cordell HJ,
Darlay R,
Andersen MK,
Fontana MC,
Martinelli G,
Marconi G,
Sanz MA,
Cervera J,
Gómez-Seguí I,
Cluzeau T,
Moreilhon C,
Raynaud S,
Sill H,
Voso MT,
Lo-Coco F,
Dombret H,
Cheok M,
Preudhomme C,
Gale RE,
Linch D,
Gaal-Wesinger J,
Masszi A,
Nowak D,
Hofmann WK,
Gilkes A,
Porkka K,
Milosevic Feenstra JD,
Kralovics R,
Grimwade D,
Meggendorfer M,
Haferlach T,
Krizsán S,
Bödör C,
Stölzel F,
Onel K,
Allan JM
Nature communications · 2021 · PMID 34716350 · open access
Questions about rs3916765
What is rs3916765?
rs3916765 is a single position in the genome, in or near the near MTCO3P1 gene. Published research associates it with acute myeloid leukemia (normal cytogenetics). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs3916765 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3916765 come from?
GWAS Catalog, Nature communications 2021, PMID:34716350. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Acute myeloid leukemia (normal cytogenetics) (rs3916765). MyGeneLog™. https://www.mygenelog.com/variants/rs3916765
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