Acute Gastritis, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 2,691 cases and 617,490 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Acute Gastritis — filed in the GWAS Catalog as "Acute gastritis (PheCode 535.1)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 5 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. The catalogue records its sample as 2,691 cases and 617,490 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). From it, 5 positions on this page: rs551168461 (ZNF385B), rs189729920 (CDH18), rs531563674 (SORCS2), rs548414295 (near KCNF1), rs564144865 (LINC01031). PMID:39024449.
The 5 positions sit in or beside 5 genes: ZNF385B, CDH18, SORCS2, KCNF1, LINC01031. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Verma A et al. 2024 reported the smallest P value on this page — P = 10-12 — at rs551168461 in ZNF385B.
It is a record of what genome-wide studies have reported about Acute Gastritis, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
A genotype does not diagnose Acute Gastritis; a clinician does. No guideline uses the 5 variants on this page to predict it, screen for it or confirm it.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Acute Gastritis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Acute Gastritis. MyGeneLog™. https://www.mygenelog.com/conditions/acute-gastritis
In the GWAS Catalog, Acute Gastritis is filed as "Acute gastritis (PheCode 535.1)". Rather than define it, this page lists the genome-wide findings: 5 positions from 1 study, each with its study's sample and citation.
Genes play a part: 5 positions have been linked to it, the largest study recording 2,691 cases and 617,490 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The catalogue maps the positions to 5 genes: ZNF385B, CDH18, SORCS2, KCNF1, LINC01031. These are where the positions sit, not proof of how they act.
No. They are population-level findings of small effect. Acute Gastritis is diagnosed by a clinician, and no guideline uses a genotype to predict it.
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